Prof.OP Kharbanda is Cheif, Centre for Dental Education and Research and Head of Orthodontics and Dentofacial Deformities at All India Institute of Medical Sciences New Delhi. He has been involved with clinical and biological research on MSI since 2004. Prof Kharbanda is a known author, reviewer and clinician. He has published widely including a Text Book on Orthodontics " Diagnosis and Mangement of Malocclusion and Dentofacial Deformities" published by Elsevier. Prof.Kharbanda has a special interest in Cleft Lip and Palate is Director of the Advanced Fellowship Program in Cleft lip and palate. He is also Director of WHO collaborating Centre on Oral Health. Dr Kharbanda is past President of the Indian Orthodontic Society, Past Editor in Chef Journal of Indian Orthodontic society, Past President Indian Society for Cleft Lip Palate and Craniofacial Anomalies and currently President of the Indian society for Dental Research, Indian Division of the International Association of Dental Research. He has been active with WIOS and is an advisory board member.

Title of Talk

Biological Phenomenon Of MSI-BONE And Gingival INTERFACE For The Stability And Clinical Success


The bone MSI interface has been studied extensively to understand the phenomenon of stability as related to the clinical success of the of the MSI. Little attention has been paid to MSI soft tissue interface, more so at the to the biological seal established at the transgingival collar region. The PMICF can provide a host of information on bone MSI interface and also status of the health of the soft tissue around MSI. This presentation will focus on evaluation of mediators in peri-implant crevicular fluid (PICF) to study the bone remodeling processes around MSIs at insertion or application of orthodontic forces when using MSIs as direct or indirect anchorage. The current literature indicates that only little (1% or so ) of biochemical and microbiological evidence regarding the success of MSIs has been explored. The research conducted at CDER on mediators including pro-inflammatory cytokines, interleukins, Matrix Metalloproteinases (MMPs). Circulating Nucleic Acids (CNA) Pentraxin 3 (PTX3). Macrophage-colony Stimulating Factor (M-CSF) and how it relates to clinical success will be presented.